An inflammation of the prostate gland, often resulting in swelling or pain. Prostatitis can result in four significant symptoms: pain, urination problems, sexual dysfunction, and general health problems, such as feeling tired and depressed. Less than 5% of cases of prostate pain are from infection, yet most healthcare professionals assume that’s the case and will try to nuke it with antibiotics. (If the prostatitis is from an infection, it might have been caused by e. coli that a man got when being a top during anal sex.) The problem often isn’t in the prostate itself, but from the tissues and muscles that surround the prostate. is a very helpful website for men with this condition. Also, see Benign Prostaic Hyperplasia (BPH).